布魯氏菌病（簡(jiǎn)稱布?。┦且环N由布魯氏菌引起的嚴(yán)重危害人和動(dòng)物健康的人獸共患病,。疫苗免疫是畜間布病流行率較高地區(qū)控制該病的重要手段。遼寧省建昌縣經(jīng)過(guò)多年實(shí)踐,，創(chuàng)新出一套免疫保護(hù)效果較好的陰道途徑免疫S2疫苗的新型家畜免疫技術(shù),。為了解該技術(shù)對(duì)家畜的安全性，本研究采用該技術(shù)免疫了3只山羊,，在免疫1個(gè)月后檢測(cè)其抗體滴度,、體內(nèi)含菌量，觀察脾臟和肝臟的病理變化,。結(jié)果顯示,，3只免疫山羊均抗體陽(yáng)轉(zhuǎn)，所有采集的臟器均未分離到布魯氏菌,，且脾臟和肝臟未出現(xiàn)布病相關(guān)病理變化,。初步研究表明，通過(guò)陰道途徑對(duì)羊進(jìn)行S2疫苗免疫是安全的,。

Preliminary Study on the Safety of Brucella Vaccine S2 Strain on

Goats Immunized via Vagina 

Brucellosis is a kind of zoonosis caused by Brucella,，which seriously endangers human and animal health，and is mainly controlled through vaccination in areas where animal brucellosis is prevalent. After practices for several years,，a new immune technology（immunization via vagina）was developed in Jianchang County of Liaoning Province,，and good immune effects have been achieved. In order to make clear the safety of the technology on animals，3 goats were vaccinated,，one month later,，their antibody titer and bacterial content were detected and the pathological changes of their spleens and livers were observed. The results showed that the antibodies in the three goats turned to be positive，no Brucella was isolated from all the organs collected,，and no pathological changes related to brucellosis were found in spleens and livers. These results preliminarily indicated that it was safe to immunize goat with Brucella vaccine S2 strain via the vagina.

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